This comprehensive analysis compares CFX and DOT, two Layer-1 blockchains with distinct DeFi positioning and performance characteristics. CFX, launched in 2020, emphasizes scalable public blockchain infrastructure with high throughput, while DOT (launched 2019) specializes in cross-chain interoperability through parachain architecture. The article examines historical price trends, current market dynamics (CFX at $0.07888, DOT at $2.231 as of January 2026), tokenomics, institutional adoption patterns, and technical ecosystems. Through 2031 price forecasts and investment strategy frameworks, the analysis addresses which asset better suits conservative, aggressive, beginning, and institutional investors. Risk assessments cover market volatility, technical execution challenges, and regulatory considerations across jurisdictions. The guide concludes that DOT suits interoperability-focused investors with larger market presence, while CFX appeals to those seeking emerging regional blockchain infrastructure exposure