Conclusion first: Monosodium glutamate (MSG) absolutely cannot cure bipolar disorder. In fact, scientific research shows that excessive intake of MSG may have negative effects on bipolar disorder or other mood disorders.

Here are the scientific reasons why "MSG treatment for bipolar disorder" is not valid:
1. Excessive "Glutamate" levels in the brain are associated with bipolar disorder
MSG's main component is "monosodium glutamate." Glutamate is the most important excitatory neurotransmitter in the brain.
• Scientific research: Many psychiatric studies have found that patients with bipolar disorder (especially during manic episodes) often have abnormally high levels of glutamate in the brain. This overexcitation can lead to neuronal damage (excitotoxicity).
• Pharmacological logic: Many medications used to stabilize mood in bipolar disorder (such as lithium or certain anticonvulsants) work by reducing or inhibiting glutamate activity to achieve a calming effect.
2. Possible effects of MSG on mood
Although normal dietary MSG usually cannot cross the blood-brain barrier in large amounts, for some sensitive individuals, excessive intake of MSG may:
• Trigger anxiety or agitation: For those already experiencing emotional instability, excessive neural stimulation may worsen anxiety.
• Increase physiological burden: Bipolar patients often require long-term medication, and excessive intake of "sodium" from MSG may affect blood pressure and even interact with certain psychiatric drugs (such as lithium), impacting metabolism and drug efficacy.
3. Where does this myth come from?
This may stem from a misunderstanding of the term "glutamate." Glutamate is indeed an essential substance for brain function and a precursor for synthesizing "GABA" (a calming neurotransmitter). However, the body self-regulates brain glutamate levels precisely. Relying on "eating" MSG to supplement or regulate brain neurotransmission is not only ineffective but may be counterproductive.